Essential Clinical Pathology

Clinical Pathology

Clinical Pathology

Essential fatty acids: biochemistry, physiology and pathology.

Essential fatty acids (EFAs), linoleic acid (LA), and alpha-linolenic acid (ALA) are essential for humans, and are freely available in the diet. Hence, EFA deficiency is extremely rare in humans. To derive the full benefits of EFAs, they need to be metabolized to their respective long-chain metabolites, i.e., dihomo-gamma-linolenic acid (DGLA), and arachidonic acid (AA) from LA; and eicosapenta...

Aids to Clinical Pathology

Clinical & Experimental Pathology

In humans, HHcy causes various symptoms such as mental retardation, epilepsy, epileptic seizures and atherosclerosis, whose pathology is not fully understood. Pro-inflammatory mediators released by activated microglia secrete various neurotoxic factors such as NO and ROS, which contribute to neuronal degeneration in neurodegenerative diseases [1,2]. Within this context, HHcy proved to cause neu...